Chiral Brønsted acid-catalyzed diastereo- and enantioselective synthesis of CF3-substituted aziridines.
نویسندگان
چکیده
A multicomponent organocatalyzed highly diastereo- and enantioselective synthesis of CF(3)-substituted aziridines is described. This reaction of in situ generated CF(3)CHN(2) and aldimines was realized by chiral Brønsted acid catalysis. The utility of the products is illustrated by easy access to β-CF(3) isocysteine and aziridine-containing dipeptides.
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 76 شماره
صفحات -
تاریخ انتشار 2012